Jan Heering Selected Research

Neoplasms (Cancer)

12/2021	Closantel is an allosteric inhibitor of human Taspase1.
10/2021	Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
11/2020	Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
10/2020	Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics.
11/2019	Structure optimization of a new class of PPARγ antagonists.
1/2019	Hybrid Reporter Gene Assays: Versatile In Vitro Tools to Characterize Nuclear Receptor Modulators.
1/2018	A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.
9/2015	FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.

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Jan Heering Research Topics

Disease

8	Neoplasms (Cancer) 12/2021 - 09/2015
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2021
2	Metabolic Diseases (Metabolic Disease) 10/2020 - 10/2018
2	Type 2 Diabetes Mellitus (MODY) 10/2020 - 10/2018
2	Inflammation (Inflammations) 02/2019 - 01/2019
1	Neuroinflammatory Diseases 10/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Central Nervous System Neoplasms 01/2021
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 10/2020
1	Mason-Type Diabetes 10/2020
1	Asthma (Bronchial Asthma) 01/2019
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Gout 10/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	HIV Infections (HIV Infection) 01/2018
1	Genomic Instability 01/2017
1	Non-alcoholic Fatty Liver Disease 01/2017
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 09/2015

Drug/Important Bio-Agent (IBA)

6	LigandsIBA 01/2022 - 10/2020
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2020
3	Proteins (Proteins, Gene)FDA Link 12/2021 - 09/2015
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2021 - 01/2019
3	Pharmaceutical PreparationsIBA 10/2020 - 01/2018
2	Epoxide HydrolasesIBA 01/2019 - 01/2017
1	indoleIBA 10/2021
1	Orphan Nuclear ReceptorsIBA 01/2021
1	Propranolol (Inderal)FDA LinkGeneric 01/2021
1	Protein Isoforms (Isoforms)IBA 11/2020
1	Hepatocyte Nuclear FactorsIBA 10/2020
1	PPAR gammaIBA 11/2019
1	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 01/2019
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2019
1	lesinuradIBA 10/2018
1	urate transporterIBA 10/2018
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2018
1	Caspase 2IBA 01/2017
1	Apoptosomes (Apoptosome)IBA 09/2015

Therapy/Procedure

2	Therapeutics 12/2021 - 09/2015